
Adaptive Biotechnologies says it’s proceeding with plans to launch a brand new sort of check to find out if somebody was beforehand contaminated with SARS-CoV-2, the virus that causes COVID-19, after a research added to the proof that its method is extra correct than presently accessible antibody checks.
The Seattle-based firm’s “T-Detect” check works by on the lookout for the distinctive signature related to COVID-19 in T cells, the specialised cells that decide the human immune system’s response to the illness. The corporate says it’s planning to launch the check publicly this fall, which might put the timing between now and Dec. 21.
In its announcement Friday morning, Adaptive stated a brand new research discovered that its check was in a position to establish 97% (68 of 70 circumstances) of SARS-CoV-2 infections that had been confirmed when lively by way of PCR diagnostic testing. By comparability, a check designed to detect antibodies produced in response to the illness recognized previous infections at a 77% fee (54 out of 70 circumstances).

“These knowledge add to the rising physique of real-world proof that the T cell performs a vital position in immunity to SARS-CoV-2,” stated Lance Baldo, the corporate’s chief medical officer, as a part of the announcement. “T cells are rising as one other key indicator for previous an infection and immunity to the novel coronavirus, and a T-cell check for sufferers that’s correct and reproducible can serve massive populations of individuals given what we’re studying in regards to the biology of the immune response.”
As well as, Adaptive stated the outcomes indicated that T-cell testing “can also establish previous infections that had been missed by prior PCR testing.”
The corporate, a spin-out of Seattle’s Fred Hutchinson Most cancers Analysis Middle, is partnering with Microsoft and utilizing its machine studying know-how as a part of the initiative.
On a associated notice, Adaptive said in a regulatory filing Thursday that its companion Amgen declined to go ahead with plans to commercialize Adaptive’s antibody that neutralize SARS-CoV-2.
“The 2 antibodies we recognized neutralize the virus at very low concentrations,” a spokesperson stated in an announcement. “They’re synergistic, and we anticipate that combining them in a cocktail may additional improve efficiency. We’re inspired by the latest progress within the combat towards COVID, however we additionally acknowledge that the virus is now endemic and efficient therapies and instruments are nonetheless wanted, and we hope that the antibodies that Adaptive found can contribute to the answer.”
Adaptive on Tuesday reported a net loss of $36.7 million for the third quarter on income of $26.three million. Shares of the corporate are up 2% in buying and selling this morning after falling three% on Thursday.